Back to Search
Start Over
A novel coumarin-based fluorescence chemosensor for Al3+ and its application in cell imaging.
- Source :
-
Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy . Mar2019, Vol. 210, p105-110. 6p. - Publication Year :
- 2019
-
Abstract
- Abstract As an efficient turn-on fluorescent chemosensor for Al3+, a new coumarin derivative (CND) has been designed and synthesized by the condensation of 8-formyl-7-hydroxycoumarin with niacin hydrazide. The spectroscopic studies revealed that the sensor CND exhibited a remarkable fluorescence enhancement towards Al3+ with high selectivity and sensitivity in EtOH-HEPES (95:5, v/v, pH = 7.40), which was attributed to the photoinduced electron transfer (PET) and C N isomerization mechanism. Fluorescence titration calculations data showed that the detection limit and the association constants of CND for Al3+ were found to be 2.51 × 10−7 M and 9.64 × 104 M−1, respectively. The results of experiments, including Job's plot, 1H NMR titration and ESI-MS, revealed that the stoichiometric binding between CND and Al3+ was 1:1. The investigations of the pH dependency of CND for Al3+ detection, and the cell imaging suggested the sensor CND could be promisingly applied for the recognition of Al3+ in biological cells. Graphical Abstract Unlabelled Image Highlights • A novel coumarin-based fluorescence sensor for Al3+ was designed and synthesized. • This sensor has good selectivity and sensitivity for Al3+. • This sensor can be applied in live cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13861425
- Volume :
- 210
- Database :
- Academic Search Index
- Journal :
- Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy
- Publication Type :
- Academic Journal
- Accession number :
- 133600675
- Full Text :
- https://doi.org/10.1016/j.saa.2018.11.006