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Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus).
- Source :
-
Aquaculture . Feb2019, Vol. 501, p473-481. 9p. - Publication Year :
- 2019
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Abstract
- Abstract The present study was conducted to evaluate the effects of dietary flavonoids from Allium mongolicum Regel (AMRF) supplementation on growth, antioxidant and immune status, immune-related genes expression and disease resistance in Channa argus. A basal diet was supplemented with AMRF at 0, 10, 20 or 40 mg/kg feed for 56 days. The result revealed that weight gain (WG) and specific growth rate (SGR) were significantly increased (P <.05) with the increase of dietary AMRF levels from 0 to 40 mg/kg. All AMRF-supplemented groups (10, 20 or 40 mg/kg) significantly enhanced (P <.05) serum AKP, lysozyme activity, C3, IgM concentration, liver antioxidant enzymes activity (SOD, CAT and GSH-Px) or decreased (P <.05) serum cortisol, liver MDA content, serum ALT and AST activity. Meanwhile, AMRF administration significantly up-regulated (P <.05) the expression of SOD, IgM, HSP70, HSP90, IκB-α and GR or down-regulated (P <.05) NF-κB p65 and inflammatory cytokines (TNF-α, IL-1β and IL-8) transcription in head kidney of C. argus. After challenge with Aeromonas hydrophila , survival rates in all AMRF treatment groups were significantly increased (P <.05). These results indicated that dietary intake containing AMRF enhanced growth, antioxidant and immune response and regulated immune-related genes expression and increased disease resistance against Aeromonas hydrophila in snakehead fish, with greatest effects in fish given 40 mg/kg AMRF for 56 days. Highlights • Flavonoids from Allium mongolicum Regel enhanced growth, antioxidant and immune response of snakehead fish. • Flavonoids from Allium mongolicum Regel regulated immune-related genes expression in snakehead fish. • Flavonoids from Allium mongolicum Regel enhanced the disease resistance against Aeromonas hydrophila in snakehead fish. • The optimum supplemented dose of flavonoids from Allium mongolicum Regel is 40 mg/kg. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448486
- Volume :
- 501
- Database :
- Academic Search Index
- Journal :
- Aquaculture
- Publication Type :
- Academic Journal
- Accession number :
- 133621472
- Full Text :
- https://doi.org/10.1016/j.aquaculture.2018.12.011