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Concise Synthesis of Polysubstituted Carbohelicenes by a C−H Activation/Radical Reaction/C−H Activation Sequence.
- Source :
-
Angewandte Chemie . Jan2019, Vol. 131 Issue 1, p308-312. 5p. - Publication Year :
- 2019
-
Abstract
- Disclosed herein is the merging of C−H activation and radical chemistry, enabling rapid access to a structurally diverse family of fused carbohelicenes through the fusion of α‐acetylnaphthalenes with alkynes under oxidative conditions. This cascade process exhibits exquisite chemoselectivity and regioselectivity. The reaction pathway was analyzed by intermediate separations, control experiments, radical trapping, EPR, MALDI‐TOF‐MS, and ESI‐HRMS experiments, and shown to involve a C2−H activation/radical reaction/C8−H activation relay. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 131
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 133628757
- Full Text :
- https://doi.org/10.1002/ange.201811023