Nickel‐Catalyzed Denitrogenative ortho‐Arylation of Benzotriazinones with Organic Boronic Acids: an Efficient Route to Losartan and Irbesartan Drug Molecules.

Denitrogenative ortho‐arylation, vinylation and methylation of 1,2,3‐benzotriazin‐4‐(3H)‐ones with organic boronic acids catalyzed by nickel complexes to give a wide range of o‐substituted benzamides were demonstrated. Further, the catalytic reaction is successfully applied to the synthesis of the popular hypertensive drugs losartan and irbesartan in high yields. [ABSTRACT FROM AUTHOR]