Ethnopharmacology of Cuscuta epithymum: A comprehensive review on ethnobotany, phytochemistry, pharmacology and toxicity.

Abstract Ethnopharmacological relevance Cuscuta epithymum (L.) L. (C. epithymum ; Convolvulaceae) is a parasitic plant that has long been used locally and traditionally in Asia, Europe and other regions. Aim of the review The study intends to reflect the significance of the C. epithymum in traditional medicine. This review aims to grant insight into the species' botany, pharmacological activities and phytochemistry with distinctive emphasis on its ethnomedicinal and traditional applications in all over the world. The review endeavors to rule out any inconsistency between the species' traditional application and its pharmacological activity, and presenting any coherence existing. Materials and methods The books on ethnomedicine and the main medieval Persian medicine textbooks including Makhzan Al- Advieh, The canon of medicine, Zakhireh kharazmshahi and etc were explored for C. epithymum. Additionally, information on the ethnobotany, phytochemistry, morphology, taxonomy, modern medicinal uses, and pharmacological activities were collected in electronic databases including Google Scholar, Science Direct, Scopus, and PubMed using the keywords " Cuscuta epithymum," "traditional medicine," "ethnomedicine," "phytochemistry," "pharmacology" and "activity." Then, the available articles from 1975 to 2017 were employed for this study. Results C. epithymum is a rootless plant, widely distributed and available in every continent except Antarctica. It was used traditionally in formularies or by rural people and as geriatric drug, detergent, purgative, disorders in the melancholic humor, joint, kidney, urinary tract, gastrointestinal system, nervous system, etc. In modern medicine, the extract of C. epithymum showed anti-microbial, cytotoxic, anticonvulsant, anti-urease, immune stimulatory, hepatoprotective effect, and antioxidant activity. The main phytochemical constituents are alkaloids; saponins; tannins; triterpenoids; steroids; carbohydrates; aromatic compounds; flavonoids and the hydroxycinnamic acid derivatives. Conclusion The modern pharmacological studies have validated the traditional and ethnobotanical uses of C. epithymum. However, many aspects of this herb have not been studied yet. In addition, information about the phytochemistry and toxicological profile is insufficient. Owing to the extensive traditional uses of C. epithymum. Hence further studies on pharmacological activities, phytochemistry, and toxicity and adverse effects seem to be necessary to appraise the medicinal values of C. epithymum. Graphical abstract fx1 [ABSTRACT FROM AUTHOR]