Synthesis and Evaluation of Anticancer Activity of Indazole Derivatives.

A novel series of indazole 13a-13j derivatives has been synthesized. Their structures are confirmed by 1H and 13C NMR, and mass spectral analysis. The compounds are tested for their anticancer activity against four human cancer cell lines including A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), using combretastatin-A4 as a positive control. Most of the synthesized compounds demonstrate potent activity against the above cell lines. Here IC50 values of target compounds range from 0.010±0.0042 to 12.8±3.77 μM and the control drug from 0.11±0.02 to 0.93±0.034 μM. The compounds 13a, 13b, 13e, 13g, 13h, and 13j are determined to be more potent than the positive control. [ABSTRACT FROM AUTHOR]