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Modelling the suppression of autoimmunity after pathogen infection.
- Source :
-
Mathematical Methods in the Applied Sciences . Dec2018, Vol. 41 Issue 18, p8565-8570. 6p. - Publication Year :
- 2018
-
Abstract
- We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 (IL‐2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells responded to a pathogen infection. In this paper, we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL‐2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a sufficiently long time, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state, and autoimmunity can be suppressed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AUTOIMMUNITY
*PATHOGENIC microorganisms
*INFECTION
*T cells
*IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 01704214
- Volume :
- 41
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Mathematical Methods in the Applied Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 133893686
- Full Text :
- https://doi.org/10.1002/mma.4899