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Complex coacervation of carboxymethyl konjac glucomannan and chitosan and coacervate characterization.
- Source :
-
International Journal of Biological Macromolecules . Feb2019, Vol. 123, p436-445. 10p. - Publication Year :
- 2019
-
Abstract
- Abstract Carboxymethyl konjac glucomannan (CMKGM) shows potential in the construction of colon-targeted delivery systems through electrostatic interaction-based techniques. Its coacervation with chitosan (CHI) was investigated as a function of degree of substitution (DS). CMKGMs displayed the same optimum coacervation conditions of pH 6.5 and mass ratio 1:1 with CHI, but the coacervate yield was positively related to their DS. The coacervation was weakened by the presence of NaCl, but was not affected in temperatures 25–75 °C and total biopolymer concentrations 0.05–0.15% (w/v). Both electrostatic interaction and hydrogen bonding were involved in the coacervation and a higher DS contributed a denser network structure, a smaller particle size, and greater elasticity. The coacervates maintained their structures in simulated gastrointestinal fluids, but could be degraded by the β-mannanase in simulated colonic fluid. Hence, CMKGMs could be used in colon-targeted and enzyme-triggered delivery systems and the delivery performance could be tailored by varying their DS. Graphical abstract Unlabelled Image Highlights • CMKGM coacervated with CHI independent of its DS. • Optimum coacervation between CMKGM and CHI occurred at pH 6.5 and mass ratio 1:1. • CMKGM – CHI coacervates could be degraded by β-glucomannase in the simulated colonic fluid. • The properties of CMKGM – CHI coacervates were closely related to the DS of CMKGM. • CMKGM could be used for the construction of colon-targeted delivery systems. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLUCOMANNAN
*CARBOXYMETHYLATION
*CHITOSAN
*COLON physiology
*DRUG delivery systems
Subjects
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 123
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 133919095
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2018.11.086