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A red emitting fluorescent probe for imaging mitochondrial hydrogen polysulfide in living cells and tissues.
- Source :
-
Sensors & Actuators B: Chemical . Feb2019, Vol. 281, p871-877. 7p. - Publication Year :
- 2019
-
Abstract
- Highlights • The probe exhibited good selectivity towards hydrogen polysulfide among other biological species. • The probe can detect hydrogen polysulfide within 10 min. • HQO-PSP has the ability of mitochondrial-targeting. • HQO-PSP can be applied not only at the level of living cells but also to mouse tissues. Abstract Hydrogen polysulfide (H 2 S n) has attracted increasing attention since H 2 S n instead of H 2 S has been shown to be the actual signaling molecule in physiological and pathological processes. Thus, developing accurate and sensitive assays for H 2 S n detection is urgently needed in biological science. In this work, we developed a red emitting mitochondria-targeting fluorescent probe, HQO-PSP, that is capable of tracking H 2 S n. With low cytotoxicity, good selectively and high sensitively, HQO-PSP was able to detect H 2 S n in living cells. Furthermore, we also demonstrated that HQO-PSP could also be successfully applied to recognize H 2 S n in living tissues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 281
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 133972315
- Full Text :
- https://doi.org/10.1016/j.snb.2018.10.155