Fusaricates H-K and fusolanones A-B from a mangrove endophytic fungus Fusarium solani HDN15-410.

Abstract Seven compounds including four undescribed fusaric acid derivatives, namely fusaricates H-K, and two undescribed γ -pyrone derivatives, named fusolanones A-B, as well as a known compound fusaric acid, were isolated from a mangrove endophytic fungus Fusarium solani. Fusaricates H-K represent the first cases of fusaric acid butanediol esters and are diastereoisomers. Their structures including absolute configurations were elucidated based on NMR, MS, chemical synthesis, chiral HPLC analysis and ECD calculations. The antibacterial activity of all undescribed compounds were tested and fusolanone B showed the best activity with MIC value 6.25 μg/mL on Vibrio parahaemolyticus. Graphical abstract Four undescribed fusaric acid derivatives and two undescribed γ -pyrone derivatives as well as fusaric acid were isolated from an endophytic fungus Fusarium solani , with fusolanone B showed the best antibacterial activity. Image 1 Highlights • Seven previously undescribed compounds were isolated from a mangrove endophytic fungus Fusarium solani. • Fusaricates H-K represent the first cases of fusaric acid butanediol esters and are diastereoisomers. • Fusolanone B showed antibacterial activity on Vibrio parahaemolyticus with MIC value 6.25 μg/mL. [ABSTRACT FROM AUTHOR]