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Donor T-cell-derived interleukin-22 promotes thymus regeneration and alleviates chronic graft-versus-host disease in murine allogeneic hematopoietic cell transplant.
- Source :
-
International Immunopharmacology . Feb2019, Vol. 67, p194-201. 8p. - Publication Year :
- 2019
-
Abstract
- Abstract Defect of thymus results in poor posttransplant immune recovery and dysfunction of immune tolerance after allogeneic hematopoietic cell transplants (allo-HCT). Improving thymus regeneration represents a potential strategy to accelerate recovery of T-cell immunity. IL-22 was reported to mediate thymus regeneration after injury. In this study, we found donor T-cell is a major source of IL-22 in allotransplant recipient. Through applying IL-22 knock out (IL-22KO) mice in allo-HCT, we found donor T-cell derived IL-22 promotes thymus regeneration in association with increased level of intra-thymic IL-22. IL-22KO T-cell-transplanted recipients show deficient thymus recovery which is reversed by injection of exogenous IL-22. T-cell derived IL-22 promotes proliferation of thymic epithelial cells (TECs) in vitro. In addition, donor T-cell derived IL-22 increases expression level of Aire in the thymus and decreases skin chronic graft-versus-host disease (GVHD). Furthermore, short-term use of exogenous IL-22 posttransplant accelerates recovery of thymus without increasing severity of acute GVHD. Our data indicate that cross-talk between T-cell and TECs is an important mechanism to mediate reconstitution of T-cell immunity after allo-HCT. Highlights • Donor T-cell derived IL-22 promotes thymus regeneration of allotransplant recipient. • Donor T-cell derived IL-22 promotes proliferation of thymic epithelial cells. • Donor T-cell derived IL-22 decreases skin chronic graft-versus-host disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*THYMUS
*CELL transplantation
*IMMUNITY
*REGENERATION (Biology)
*INJECTIONS
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 67
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 134115167
- Full Text :
- https://doi.org/10.1016/j.intimp.2018.12.023