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Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction.
- Source :
-
Chemical Communications . 1/7/2019, Vol. 55 Issue 2, p163-166. 4p. - Publication Year :
- 2019
-
Abstract
- An unprecedented strategy of a rhodium-catalysed redox-neutral cascade reaction starting from benzamides and cyclopropenones via addition of a C–H bond into a polar carbonyl group for the rapid assembly of cyclopentene spiroisoindolinones has been developed. Water was produced as the sole by-product. Metal migration and abstraction of a H-atom from the arylcyclopropenone's aromatic ring are the key steps in building the spirocycle. Two C–C bonds, one C–N bond and an N-substituted quaternary carbon center were formed sequentially in a one pot manner. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLOPENTENES
*RHODIUM
*CARBONYL group
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 134156058
- Full Text :
- https://doi.org/10.1039/c8cc08081j