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Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma.

Authors :
Donk, Niels W. C. J.
Casneuf, Tineke
Di Cara, Alessandro
Parren, Paul W.
Zweegman, Sonja
Kessel, Berris
Lokhorst, Henk M.
Usmani, Saad Z.
Lonial, Sagar
Richardson, Paul G.
Chiu, Christopher
Mutis, Tuna
Nijhof, Inger S.
Sasser, A. Kate
Source :
British Journal of Haematology. Feb2019, Vol. 184 Issue 3, p475-479. 5p. 2 Graphs.
Publication Year :
2019

Abstract

The article informs on a study for analysing the impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma. It examines effect of Fc portion of IgG polymorphisms on response, survival, and infusion-related reactions in multiple myeloma patients treated with daratumumab drug as single agent in the GEN501 and SIRIUS studies.

Details

Language :
English
ISSN :
00071048
Volume :
184
Issue :
3
Database :
Academic Search Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
134216582
Full Text :
https://doi.org/10.1111/bjh.15122