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An ESIPT based chromogenic and fluorescent ratiometric probe for Zn2+ with imaging in live cells and tissues.
- Source :
-
New Journal of Chemistry . 1/28/2019, Vol. 43 Issue 4, p1857-1863. 7p. - Publication Year :
- 2019
-
Abstract
- A new ESIPT based fluorescent probe has been introduced for selective detection of Zn2+ in human breast cancer cells. The designed probe exhibits a prominent ratiometric fluorescence change along with a sharp blue shift of ∼71 nm which can be attributed to the hampering of the ESIPT process. The probe is efficient enough to detect Zn2+ solely in the presence of other biologically relevant cations with a limit of detection value of 1.6 × 10−7 M. The experimentally observed changes in the structure and absorption properties of the probe after complete addition of Zn2+ were further studied by density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. Moreover, the dip-stick experiment with this probe displays both absorption and fluorescence color changes after exposure to Zn2+ which also turns out to be a potential application for the probe. Live cell imaging studies have been carried out using human breast cancer cells (MCF-7) and tissues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 43
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134219987
- Full Text :
- https://doi.org/10.1039/c8nj04695f