Association between adiponectin T94G polymorphism and resistant hypertension in young-onset Taiwanese patients.

Abstract Young-onset hypertensives (YOHs) with resistant hypertension (RH) have a greater long-term cardiovascular risk. The present study examined whether a functional adiponectin T94G polymorphism (rs2241766) is associated with RH in YOHs. We analyzed data from the Academia Sinica Collaborative Study on Hypertension Genetics in Taiwanese subjects to compare rs2241766 between YOHs with and without RH (≤50 years of age). RH was defined as the need for at least 3 drugs, including a diuretic to control blood pressure. Genotyping of rs2241766 was performed using TaqMan allelic discrimination. A total of 861 YOHs were enrolled and 54 had RH in enrolled population. For the rs2241766 in the allelic model, the odds ratio (OR) of RH allele frequency was 2.45 (p = 0.008), and there was a linear relationship between allele numbers and the presence of RH (p = 0.005). In multivariate analysis, the rs2241766 (OR = 2.766, p = 0.002), age (OR = 1.103, p = 0.001), uric acid (OR = 1.322, p = 0.001), high-sensitivity C-reactive protein (OR = 2.769, p = 0.001) and aldosterone (OR = 1.004, p = 0.001) were independently associated with the presence of RH. In the Taiwanese population, the adiponectin T94G polymorphism (rs2241766) is associated with RH in YOHs. Highlights • YOHs with RH patients have a greater cardiovascular risk but the association of adiponectin T94G polymorphism is unknown. • Total 861 YOHs in Taiwanese subjects were collected to compare rs2241766 between YOHs with and without RH (≤50 year-old) • In this study, we found inflammation and hyperaldosteronism might play important roles in young-onset RH. • We also found the adiponectin T94G polymorphism (rs2241766) was independently associated with RH. • An increasing G allele frequency and heterozygous TG genotype of adiponectin gene showed a significant association with RH. [ABSTRACT FROM AUTHOR]