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Decreased serum magnesium levels in depression: a systematic review and meta-analysis.
- Source :
-
Nordic Journal of Psychiatry . Oct2018, Vol. 72 Issue 7, p534-541. 8p. - Publication Year :
- 2018
-
Abstract
- Background: Magnesium (Mg2+), an endogenous N-methyl-D-aspartate receptor antagonist, has received increased attention recently because of its role in the pathophysiology of and treatment response in depression. However, whether Mg2+ level is decreased in depression is not firmly established. We aimed to conduct a systematic review and meta-analysis to help making consensus for the association between Mg2+ levels and depression. Methods: A systematic search was conducted in the electronic database resources PubMed and Embase. After a careful selection of relevant studies, a meta-analysis using the random effects model was conducted in each measuring source, such as serum, plasma, and cerebrospinal fluid (CSF). Results: A total of 18 studies were included in this study. Among 11 studies that measured Mg2+ in the serum, Mg2+ level was lower in patients with depression than in controls (weighted mean difference = −.088, 95% confidence interval = −.164 to −.012). In the sensitivity analysis by removing studies one by one, 2 out of the 11 studies obliterated such significant differences. There were no significant differences in the Mg2+ levels in the studies for plasma and CSF. Conclusions: Despite some evidence supporting an association between decreased Mg2+ levels and depression from studies with serum, the results of our meta-analysis urge to use caution when associating Mg2+ levels and depression. Future studies are needed to establish a consensus for the role of low Mg2+ levels in depression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08039488
- Volume :
- 72
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Nordic Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 134265604
- Full Text :
- https://doi.org/10.1080/08039488.2018.1538388