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Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid.
- Source :
-
Journal of Young Pharmacists . Jan-Mar2019, Vol. 11 Issue 1, p12-16. 5p. - Publication Year :
- 2019
-
Abstract
- Objective: Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample. Method: This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule. Result: The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol. Conclusion: Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09751483
- Volume :
- 11
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Young Pharmacists
- Publication Type :
- Academic Journal
- Accession number :
- 134271853
- Full Text :
- https://doi.org/10.5530/jyp.2019.11.3