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Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy
- Source :
-
Biomaterials . Oct2004, Vol. 25 Issue 23, p5395-5403. 9p. - Publication Year :
- 2004
-
Abstract
- A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4 V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70 h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation. [Copyright &y& Elsevier]
- Subjects :
- *TITANIUM alloys
*CALCIUM phosphate
*PROTEINS
*PRECIPITATION (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 25
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 13429636
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2003.12.045