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Synthesis of alkyl dithiocarbamates by using thiuram disulfide reagents: A metal-free C(sp3)-S bond formation.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Feb2019, Vol. 60 Issue 8, p617-620. 4p. - Publication Year :
- 2019
-
Abstract
- Graphical abstract Highlights • 30 Alkyl Dithiocarbamate derivatives are synthesized in good to excellent yields. • The substrates are cheap and environmentally benign. • The methodology features efficiency, transition-metal-free and easy performance. Abstract An efficient and environmentally benign protocol for the synthesis of S -alkyl dithiocarbamates has been achieved. By reacting tetraalkylthiuram disulfides with alkyl halides, the desired products could be obtained in good to excellent yields. The methodology features efficiency, transition-metal-free, nice yields and easy performance, illustrating it practical synthetic value for the convenient preparation of some potential biologically active molecules. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DITHIOCARBAMATES
*ALKYL group
*BOND formation mechanism
*DISULFIDES
*HALOALKANES
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 60
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134530748
- Full Text :
- https://doi.org/10.1016/j.tetlet.2019.01.044