Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Authors :: Luterbach, Courtney L
Boshe, Ashley
Henderson, Heather I
Cober, Eric
Richter, Sandra S
Salata, Robert A
Kalayjian, Robert C
Watkins, Richard R
Hujer, Andrea M
Hujer, Kristine M
Rudin, Susan D
Domitrovic, T Nicholas
Doi, Yohei
Kaye, Keith S
Evans, Scott
Fowler, Vance G
Bonomo, Robert A
Duin, David van
Source :: Open Forum Infectious Diseases. Jan2019, Vol. 6 Issue 1, pN.PAG-N.PAG. 1p.
Publication Year :: 2019
Abstract: In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections. [ABSTRACT FROM AUTHOR]

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