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Alkylation of 3-Trifluoromethyl-1,2-dihydroquinoxalin-2-one.
- Source :
-
Russian Journal of Organic Chemistry . Nov2018, Vol. 54 Issue 11, p1702-1709. 8p. 6 Diagrams, 3 Charts. - Publication Year :
- 2018
-
Abstract
- O and N centers of 3-trifluoromethyl-1,2-dihydroquinoxalin-2-one anion shows in reactions with haloalkanes an ambident nucleophilic character. The chemoselectivity of the reaction depends on the alkylating agent: the methylation of 3-trifluoromethyl-1,2-dihydroquinoxalin-2-one in acetonitrile in the presence of K2CO3 yields only an N-methyl isomer whereas under the same conditions in the reaction with (4-bromobutyl)-acetate О- and N-alkylations are competing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 54
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134563265
- Full Text :
- https://doi.org/10.1134/S1070428018110131