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High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Feb2019, Vol. 174, p435-442. 8p. - Publication Year :
- 2019
-
Abstract
- Graphical abstract Highlights • Penicillin G loaded ZnAl-layered double hydroxide with a varied amount of Penicillin G were prepared firstly. • Pristine ZnAl-layered double hydroxide had some inhibition to Escherichia coli for the first time. • Nanocomposites with much higher cost-effectiveness showed a potent antimicrobial activity for up to 10 days. • The antibiotic and the carrier in novel nanocomposites strongly synergize each other in antibacterial activity. Abstract Antibiotic-resistant bacterial infections are a global health problem. A commonly-used antibiotic Penicillin G was incorporated into ZnAl-layered double hydroxides (PNG/LDH) with a varied amount of PNG. PNG/LDH nanocomposites were well characterized in structure and composition using elemental analysis, X-ray diffraction pattern, Fourier transform infrared spectroscopy and TEM images, revealing that PNG were mostly adsorbed on the LDH surfaces at a lower PNG loading but some were intercalated into LDH interlayers at a higher PNG loading. The typical release profile of PNG and Zn2+ from PNG/LDH was a quick release, followed by a sustainable slow release. The antibacterial tests against Escherichia coli demonstrated that PNG/LDH with a suitable composition synergistically improved bacterial inhibition compared with free PNG and pristine LDHs. In specific, PNG/LDH with much higher cost-effectiveness showed a potent antimicrobial activity and maintained the activity for up to 10 days, significantly elongating the antibacterial effect compared with just 1 day for free PNG in the same conditions. Our results suggest suitable composition of nanoparticle carriers and antibiotics could significantly enhance antibacterial activity of antibiotics for a long period via the synergistic effect between carrier and antibiotics, a potential approach to overcome the bacterial resistance to antibiotics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 174
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 134572678
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2018.11.035