Copper‐Catalyzed Synthesis of 13‐Aminoisoquinolino[2,1‐a]perimidine‐12‐carboxylates via α‐Arylation with a High Chemoselectivity.

The α‐arylation between cyanoacetate and 2‐(2‐bromophenyl)‐1H‐perimidine took place first catalyzed by CuI/L‐proline in the presence of NaHCO3, and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13‐aminoisoquinolino[2,1‐a]perimidine‐12‐carboxylate derivatives in good yields. [ABSTRACT FROM AUTHOR]