依折麦布致严重关节疼痛一例.

A 63-year-old male patient was given Rosuvastatin calcium tablets combined with Ezetimibe tablets; after 1 week, the patient felt arthralgia in hands; at about 1-month continuous administration, the symptom of arthralgia became unbearable and the patient could not walk; at 1 week after drug withdrawl, the symptoms of arthralgia had disappeared completely, while the administartion of Rosuvastatin calcium tablets was not interrupted. The patient was constantly given Rosuvastatin calcium tablets at before, during and after the occurrence of adverse drug reactions. Therefore, the occurrence of adverse drug reactions was clearly related to the application of ezetimibe. The dispensatory indicates that arthralgia is an uncommon adverse drug reaction of ezetimibe. In this case, the association between arthralgia and ezetimibe is “very likely”. It is suggested that when the patient encounters an unexplained arthralgia during medication, the adverse drug reaction should be excluded first. [ABSTRACT FROM AUTHOR]