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Suppression of myosin-induced and adoptively transferred myocarditis by prior treatment with complete Freund's adjuvant
- Source :
-
Cardiovascular Pathology . Jul2004, Vol. 13 Issue 4, p221-224. 4p. - Publication Year :
- 2004
-
Abstract
- Background: We evaluated the effect of pretreatment with complete Freund''s adjuvant (CFA) on experimentally induced myocarditis concomitant with the assessment of antigen-specific properties of disease-triggering lymphocytes.Methods and results: Rats pretreated with CFA a week prior to myosin immunization developed a significantly attenuated myocardial inflammation as compared to control-treated animals. Furthermore, prior administration of CFA virtually abolished histological evidence of myocarditis induced by transfer of antimyosin lymphocytes.CFA administered subcutaneously prior to myosin immunization resulted in a significant reduction in lymph node cell reactivity to myosin. Assessment of cultured medium from lymphocytes obtained from CFA-pretreated myosin-immunized rats revealed reduced levels of interferon gamma but an increased production of IL-10, suggesting an induction of a Thl to Th2 switch.Conclusions: Thus, CFA treatment suppressed both myosin-induced as well as adoptively transferred myocarditis concomitant with induction of antigen-specific unresponsiveness to myosin and skewing of the immune response in favor of a Th2-dominated profile. [Copyright &y& Elsevier]
- Subjects :
- *MYOSIN
*MYOCARDITIS
*IMMUNE system
*IMMUNOLOGICAL adjuvants
Subjects
Details
- Language :
- English
- ISSN :
- 10548807
- Volume :
- 13
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 13471293
- Full Text :
- https://doi.org/10.1016/j.carpath.2004.02.002