Back to Search
Start Over
Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose.
- Source :
-
International Journal of Molecular Sciences . Feb2019, Vol. 20 Issue 3, p697. 1p. 2 Diagrams, 4 Graphs. - Publication Year :
- 2019
-
Abstract
- The glucose analog, 2-deoxyglucose (2-DG), specifically inhibits glycolysis of cancer cells and interferes with the growth of cancer cells. However, the excellent water solubility of 2-DG makes it difficult to be concentrated in tumor cells. In this study, a targeted nano-pharmacosome was developed with folic acid-modified 2-DG (FA-2-DG) by using amino ethanol as a cleavable linker. FA-2-DG was able to self-assemble, forming nano-particles with diameters of 10–30 nm. The biological effects were evaluated with cell viability assays and flow cytometry analysis. Compared with a physical mixture of folic acid and 2-DG, FA-2-DG clearly reduced cell viability and resulted in cell cycle arrest. A computational study involving docking simulation suggested that FA-2-DG can dock into the same receptor as folic acid, thus confirming that the structural modification did not affect the targeting performance. The results indicated that the nano-pharmacosome consisting of FA-2-DG can be used for targeting in a nano-drug delivery system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLYCOLYSIS
*FLOW cytometry
*NANOPARTICLES
*ETHANOL
*DRUG delivery systems
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 20
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 134800953
- Full Text :
- https://doi.org/10.3390/ijms20030697