Back to Search
Start Over
CD4 + CXCR4 + T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease.
- Source :
-
Rheumatology . Mar2019, Vol. 58 Issue 3, p511-521. 11p. 3 Charts, 4 Graphs. - Publication Year :
- 2019
-
Abstract
- Backgroud There is an unmet need for the development of new biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD). Methods Peripheral CD4+CXCR4+ T cells, stromal cell-derived factor-1 and Krebs von den Lungen-6 were measured in patients with IIM-ILD (n = 85) and controls. The relation to pulmonary functions, high-resolution CT scores, specific clinical phenotypes and survival was analysed. Cytokine-expression profiling of these CD4+CXCR4+ T cells and their co-culture with pulmonary fibroblasts were conducted. Results The peripheral percentages of CD4+CXCR4+ T cells were significantly elevated in IIM-ILD patients, and correlated with high-resolution CT score (r = 0.7136, P < 0.0001) and pulmonary function impairments, such as percentage of forced volume vital capacity (r = −0.4734, P = 0.0005). They were associated with anti-melanoma differentiation-associated gene 5 autoantibodies and the amyopathic DM phenotype. In IIM-ILD, peripheral percentages of CD4+CXCR4+ T cells ⩾30% revealed a 6-month mortality as high as 47%. These CD4+CXCR4+ T cells express high levels of IL-21 and IL-6. In vitro blockade of IL-21 signalling by neutralization of IL-21 or Janus kinase inhibitor could abolished the fibroblast proliferation. Conclusion Overall, peripheral CD4+CXCR4+ T cells appear to be a potentially valuable novel biomarker associated with the severity and prognosis of IIM-ILD. They promote pulmonary fibroblast proliferation via IL-21, which may herald future targeted treatments for this severe disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL proliferation
*AUTOANTIBODIES
*BIOMARKERS
*CELL receptors
*CELLULAR signal transduction
*COMPUTED tomography
*CYTOKINES
*FIBROBLASTS
*INTERLEUKINS
*INTERSTITIAL lung diseases
*LUNGS
*MEDICAL needs assessment
*MYOSITIS
*NEUROTRANSMITTER uptake inhibitors
*RESPIRATORY measurements
*SURVIVAL analysis (Biometry)
*T cells
*CD4 antigen
*PHENOTYPES
*SEVERITY of illness index
*GENE expression profiling
*IN vitro studies
*JANUS kinases
*BLOOD
*DISEASE complications
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 58
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 134845852
- Full Text :
- https://doi.org/10.1093/rheumatology/key341