ZMĚNY FRAKČNÍ ANIZOTROPIE BÍLÉ HMOTY MOZKOVÉ U NEMOCNÝCH PO PRVNÍ EPIZODĚ SCHIZOFRENIE.

Purpose: To assess microstructural changes of the cerebral white matter in the earliest stage of schizophrenia. Methods: Magnetic resonance was used to prospectively compare fractional anisotropy of the white matter between subjects after the first episode of schizophrenia (n = 23) and healthy controls (n = 23). Diffusion tensor data obtained from multidirectional diffusion weighted sequence were analysed by using Tract-Based Spatial Statistics (TBSS). Results: Extensive areas of decreased fractional anisotropy (FA) were found in the white matter after the first episode of schizophrenia, affecting most of the white matter tracts. No areas of significantly increased FA were found when compared to the healthy control group. Conclusion: Extensive areas of microstructural alteration of the white matter are already present during the first episode of schizophrenia. [ABSTRACT FROM AUTHOR]