使用富血小板血浆对下肢慢性创面缺损的临床研究分析.

Objective: To study the characteristics of platelet rich plasma(PRP) in the treatment of lower limb skin defect and to find out the most suitable treatment for lower limb skin defect with no surgical indications. Methods: From 2016.03 to 2017.03, 16 patients diagnosed as lower limb skin defect were included in the research. 8 patients were treated by platelet rich plasma, while 8patients received conservative treatment with recombinant human epidermal growth factor gel. Remove residual hemostatic gauze and dried blood every and change the new drug 7 days and observe the healing of the wound. Results: We observed that the scabby appeared in the skin defect, and there was no leakage in the wound in seventh day in all patients. The area was reduced about 1/4 in study group,1/6 in group in 7 days in control group. The control group were observed after 1 week, 1 case with infection, give again complementary makings bandage after debridement and using antibiotics. The area was reduced about 2/3 in experimental group, 1/4 in group in 14 days in control group. 3 weeks after treatment, the experimental group patients have been healed by more than 85% of the wound. With delayed 1-2 weeks after treatment all of the patients of this group had healing. Two patients in control group patients in the treatment of three weeks had more than 50% healing area who were continued to use this treatment method. The remaining 6 patients underwent surgical treatment(VSD) + skin graft/flap whose area reduced about 1/5. Comparing to the control group, the area of group A and B was significantly reduced(P <0.05). The area of study group was significantly reduced than the control groups(P < 0.05). Conclusions: The therapy of PRP can promote wound healing, shorten hospitalization time, reduce laid-in-bed complications, reduce the economic burden in the treatment of lower limb skin defect. [ABSTRACT FROM AUTHOR]