Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs.

Abstract Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1 – 4 compounds using 5-nitro-8-hydroxyquinoline and 5 – 8 compounds using 5-chloro-8-hydroxyquinoline. These coordination compounds were characterized by elemental analysis and 1H NMR, IR, UV–Vis and fluorescence spectroscopies, representing the coherent data matched all compounds. Myelotoxicity data, as well as the biochemical data, depicted the compounds have low cytotoxicity towards the blood cells. All coordination compounds displayed slight antimicrobial activity against E. coli , S. aureus , P. aeruginosa and E. faecalis ; [RuCl(NO)(5-chloro-8-oxyquinoline) 2 ] compound (8) represent the best result to inhibitions of Gram-positive and Gram-negative bacteria. Antineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline) 2 Cl] compound (4) as a potential chemotherapeutic agent against MCF-7 (a breast cancer cell line), compared to cisplatin (Platistine® CS) and cyclophosphamide (Genuxal®) drugs. Graphical abstract Antineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline) 2 Cl] complex (4) as potential chemotherapeutic against MCF-7 (a breast cancer cell line), comparing to cisplatin (Platistine® CS). Unlabelled Image Highlights • Synthesized new compounds showed fluorescent properties and biological activities. • All compounds offer potential applications to antibacterial and antineoplasic drugs. • Myelotoxicity data depicted the compounds have low cytotoxicity towards the blood cells. • Compounds displayed antimicrobial activity against E. coli , S. aureus , P. aeruginosa and E. faecalis. • Antineoplasic action depicted compound (4) as potential chemotherapeutic against MCF-7. [ABSTRACT FROM AUTHOR]