Function of local circuits in the hippocampal dentate gyrus-CA3 system.

Highlights • Hippocampal DG-CA3 is important for pattern separation and completion. • DG-CA3 dynamics is coordinated differently during waking and non-REM sleep. • Granule cells and mossy cells in DG have distinct spatial representations. • Granule cells show weaker pattern separation compared to downstream targets. • Contribution of DG to pattern separation in CA3 needs to be reevaluated. Abstract Anatomical observations, theoretical work and lesioning experiments have supported the idea that the CA3 in the hippocampus is important for encoding, storage and retrieval of memory while the dentate gyrus (DG) is important for the pattern separation of the incoming inputs from the entorhinal cortex. Study of the presumed function of the dentate gyrus in pattern separation has been hampered by the lack of reliable methods to identify different excitatory cell types in the DG. Recent papers have identified different cell types in the DG, in awake behaving animals, with more reliable methods. These studies have revealed each cell type's spatial representation as well as their involvement in pattern separation. Moreover, chronic electrophysiological recording from sleeping and waking animals also provided more insights into the operation of the DG-CA3 system for memory encoding and retrieval. This article will review the local circuit architectures and physiological properties of the DG-CA3 system and discuss how the local circuit in the DG-CA3 may function, incorporating recent physiological findings in the DG-CA3 system. [ABSTRACT FROM AUTHOR]