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Nickel-catalyzed alkyl–alkyl cross-coupling reactions of non-activated secondary alkyl bromides with aldehydes as alkyl carbanion equivalents.
- Source :
-
Chemical Communications . 3/7/2019, Vol. 55 Issue 19, p2793-2796. 4p. - Publication Year :
- 2019
-
Abstract
- A novel nickel-catalyzed alkyl–alkyl cross coupling of non-activated secondary alkyl bromides with aldehydes via hydrazone intermediates has been developed. Aldehydes as alkyl carbanion equivalents replace traditional organometallic reagents. This coupling occurs on the carbon of the hydrazone rather than the nitrogen. In addition, non-activated primary and tertiary alkyl bromides also undergo the cross-coupling reaction to form new C(sp3)–C(sp3) bonds in moderate yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NICKEL catalysts
*COUPLING reactions (Chemistry)
*BROMIDES
*ALDEHYDES
*CARBANIONS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 135010810
- Full Text :
- https://doi.org/10.1039/c9cc00307j