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Long-term survival and clinical forms in the acute phase of Chikungunya virus infection in older Caribbeans.
- Source :
-
Tropical Medicine & International Health . Mar2019, Vol. 24 Issue 3, p363-370. 8p. 4 Charts, 1 Graph. - Publication Year :
- 2019
-
Abstract
- <bold>Objective: </bold>To investigate whether the long-term survival in elderly patients with prior Chikungunya virus infection (CVI) is associated with the clinical form presented in the acute phase, as defined by the WHO classification.<bold>Methods: </bold>Retrospective cohort study performed in Martinique University Hospitals. Patients who attended the emergency department for suspected CVI, and who had a positive biological diagnosis of CVI by reverse transcription-polymerase chain reaction on a plasma sample between 10 January and 31 December 2014 were eligible for inclusion. Time-to-death was the primary outcome. The independent relationship between clinical forms and time-to-death was analysed using a Cox model.<bold>Results: </bold>In total, 268 patients were included. Mean age was 80 ± 8 years, 53% were women. Median length of follow-up was 28 months (range: 0-39). During follow-up, 53 (19.8%) patients died. Median survival time was 13.2 months (range: 0-33.6). At the end of follow-up, death rates were 4.6% for acute clinical cases, 19.0% for atypical cases, 19.2% for severe acute cases and 23.5% for unclassifiable cases. By multivariable analysis, the clinical form of CVI at admission was found to be independently associated with long-term survival (atypical form: HR = 2.38; 95% CI = 2.15-2.62; severe acute form: HR = 2.40; 95% CI = 2.17-2.64; unclassifiable form: HR = 2.28; 95% CI = 2.06-2.51).<bold>Conclusion: </bold>The clinical form at presentation with CVI has a significant impact on long-term survival. Management of CVI patients should be tailored according to their clinical form at admission. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHIKUNGUNYA
*CHIKUNGUNYA virus
*OLDER patients
*DEATH rate
*PROGNOSIS
*NOSOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 13602276
- Volume :
- 24
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Tropical Medicine & International Health
- Publication Type :
- Academic Journal
- Accession number :
- 135018946
- Full Text :
- https://doi.org/10.1111/tmi.13194