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CD3+CD20+ T cells and their roles in human diseases.
- Source :
-
Human Immunology . Mar2019, Vol. 80 Issue 3, p191-194. 4p. - Publication Year :
- 2019
-
Abstract
- Abstract CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3–5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20− T cells. Recently, emerging studies have shown a pathogenic behavior of CD3+CD20+ T cells in autoimmune diseases and CD20+ T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. However, CD3+CD20+ T cells may also play a protective role in ovarian cancer and HIV infection for their strong propensity to IFN-γ production. In this review, we will describe the current knowledge about CD3+CD20+ T-cell biology, and discuss their functional roles in autoimmune diseases as well as cancer and infectious diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*HUMAN T cells
*HIV infections
*CELL populations
*AUTOIMMUNE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 80
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 135055305
- Full Text :
- https://doi.org/10.1016/j.humimm.2019.01.001