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Effects of exosomes on pre-metastatic niche formation in tumors.
- Source :
-
Molecular Cancer . 3/11/2019, Vol. 18 Issue 1, pN.PAG-N.PAG. 1p. 3 Diagrams. - Publication Year :
- 2019
-
Abstract
- A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TUMORS
*EXOSOMES
*TUMOR microenvironment
*IMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 14764598
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Molecular Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 135229506
- Full Text :
- https://doi.org/10.1186/s12943-019-0995-1