Effects of acetylsalicylic acid on rats: An experimental study in azaserine-rat model.

<bold>Aim: </bold>The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis.<bold>Materials and Methods: </bold>ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period.<bold>Results: </bold>Changes in the hepatic, pancreatic, and renal -SH contents were also determined.<bold>Conclusion: </bold>Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH. [ABSTRACT FROM AUTHOR]