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Simultaneous Visualization of Endogenous Homocysteine, Cysteine, Glutathione, and their Transformation through Different Fluorescence Channels.
- Source :
-
Angewandte Chemie . 3/26/2019, Vol. 131 Issue 14, p4605-4609. 5p. - Publication Year :
- 2019
-
Abstract
- Studying numerous biologically important species simultaneously is crucial to understanding cellular functions and the root causes of related diseases. Direct visualization of endogenous biothiols in biological systems is of great value to understanding their biological roles. Herein, a novel multi‐signal fluorescent probe was rationally designed and exploited for the simultaneous sensing of homocysteine (Hcy), cysteine (Cys), and glutathione (GSH) using different emission channels. This probe was successfully applied to the simultaneous discrimination between and visualization of endogenous Hcy, Cys, GSH, and their transformation in living cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HOMOCYSTEINE
*CYSTEINE
*CHEMICAL amplification
*FLUORESCENCE spectroscopy
*THIOLS
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 131
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 135426491
- Full Text :
- https://doi.org/10.1002/ange.201813935