Back to Search
Start Over
iPLA2β and its role in male fertility, neurological disorders, metabolic disorders, and inflammation.
- Source :
-
BBA - Molecular & Cell Biology of Lipids . Jun2019, Vol. 1864 Issue 6, p846-860. 15p. - Publication Year :
- 2019
-
Abstract
- Abstract The Ca2+-independent phospholipases, designated as group VI iPLA 2 s, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLA 2 s are ubiquitously expressed, share a consensus GXSXG catalytic motif, and exhibit organelle/cell-specific localization. Among the iPLA 2 s, iPLA 2 β has received wide attention as it is recognized to be involved in membrane remodeling, cell proliferation, cell death, and signal transduction. Ongoing studies implicate participation of iPLA 2 β in a variety of disease processes including cancer, cardiovascular abnormalities, glaucoma, and peridonditis. This review will focus on iPLA 2 β and its links to male fertility, neurological disorders, metabolic disorders, and inflammation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUROLOGICAL disorders
*METABOLIC disorders
*FERTILITY
*INFLAMMATION
*ORGANELLES
Subjects
Details
- Language :
- English
- ISSN :
- 13881981
- Volume :
- 1864
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- BBA - Molecular & Cell Biology of Lipids
- Publication Type :
- Academic Journal
- Accession number :
- 135428511
- Full Text :
- https://doi.org/10.1016/j.bbalip.2018.10.010