Back to Search
Start Over
Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2019, Vol. 60 Issue 15, p1075-1078. 4p. - Publication Year :
- 2019
-
Abstract
- Graphical abstract Highlights • The first cross-dehydrogenative coupling of secondary benzylic ethers. • Isochroman-based tertiary ether synthesis in high efficiency. • Coupling of α-substituted isochromans with indoles and pyrroles. • The first example of catalytic asymmetric cross-dehydrogenative coupling leading to quaternary center. Abstract Current studies on cross-dehydrogenative coupling of benzylic ethers for new C–C bond construction predominantly focus on primary ether moieties. Oxidative cross-coupling of secondary benzylic ethers remains elusive. Herein, we describe the first cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles for tertiary ether construction. A broad range of α-aryl substituted isochromans react with a variety of electronically varied indoles and pyrroles smoothly under mild metal-free conditions in high efficiency. In addition, the catalytic asymmetric variant was preliminarily explored, and corresponding tertiary ether was obtained in 69% ee. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ETHERS
*ETHER synthesis
*INDOLE
*PYRROLES
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 60
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 135513126
- Full Text :
- https://doi.org/10.1016/j.tetlet.2019.03.032