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Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells.
- Source :
-
Microbes & Infection . Mar2019, Vol. 21 Issue 2, p99-103. 5p. - Publication Year :
- 2019
-
Abstract
- Abstract The core PI-2b pilus present in "hypervirulent" ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep , are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12864579
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Microbes & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 135625350
- Full Text :
- https://doi.org/10.1016/j.micinf.2018.10.004