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Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity.
- Source :
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Bioorganic & Medicinal Chemistry Letters . May2019, Vol. 29 Issue 10, p1162-1167. 6p. - Publication Year :
- 2019
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Abstract
- Graphical abstract Highlights • Five new sesquiterpenoids were isolated from the rhizomes of Homalomena occulta. • Compound 5 represented the first example of 1,4-oxa-oppositane sesquiterpenoid. • Compounds 5 , 18 , 19 showed potent anti-inflammatory activity. Abstract The rhizomes of Homalomena occulta are called Qian-nian-jian in Traditional Chinese Medicine (TCM), which is widely consumed in China owing to its health benefits for the treatment of rheumatoid arthritis and for strengthening tendons and bones. A phytochemical investigation on this famous TCM yielded 19 sesquiterpenoids (1 – 19) with various carbocyclic skeletons including isodaucane (2 , 8 , and 9), guaiane (3), eudesmane (4 and 10 – 15), oppositane (5 , 16 , and 17), and aromadendrane (18 and 19) types. The structures of new compounds, Homalomenins A-E (1 – 5), were determined by diverse spectroscopic data. Compound 1 possessed a rare sesquiterpenoid skeleton and compound 5 represented the first example of 1,4-oxa-oppositane sesquiterpenoid. These isolates were evaluated for their inhibitory effects on COX-2 mRNA, COX-2 protein expression, and prostaglandin E2 (PGE2) production in Raw264.7 cells, which demonstrated that compounds 5 , 18 , 19 showed potent anti-inflammatory activity by suppressing LPS-induced COX-2 expression and PGE2 production in a dose-dependent manner. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 29
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 135686761
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.03.031