1528: RESUSCITATIVE EFFECT OF CENTHAQUIN ON RENAL MEDULLARY BLOOD FLOW IN A RAT MODEL OF HEMORRHAGIC SHOCK.

B Learning Objectives: b Hemorrhagic shock (HS) accompanied by circulatory failure is a major cause of morbidity and mortality, and is often complicated by acute kidney injury (AKI). Hemorrhage was induced by withdrawing blood to a mean arterial pressure (MAP) of 35 mm Hg for 30 minutes, after which resuscitation was performed with either normal saline (NS), high-dose centhaquin (0.1 mg/kg), or low-dose centhaquin (0.01 mg/kg), to reach 100% of the shed blood volume. B Results: b Low-dose centhaquin was more effective in improving MAP in both male and female rats compared to NS or high-dose centhaquin. [Extracted from the article]