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A comprehensive study of oxidative stress in patients with somatic symptom disorder.
- Source :
-
Acta Neuropsychiatrica . Apr2019, Vol. 31 Issue 2, p100-105. 6p. - Publication Year :
- 2019
-
Abstract
- Objective: To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5. Methods: The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups. Results: TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p < 0.001). There was no significant difference in PON, ARE, and TAS parameters between the two groups (p > 0.05). Conclusion: This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09242708
- Volume :
- 31
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Neuropsychiatrica
- Publication Type :
- Academic Journal
- Accession number :
- 135698676
- Full Text :
- https://doi.org/10.1017/neu.2018.33