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General and selective syn-carboxylation-trifluoromethylation of terminal alkynes: application to the late-stage modification of dehydrocholic acid.
- Source :
-
Chemical Communications . 4/11/2019, Vol. 55 Issue 28, p4099-4102. 4p. - Publication Year :
- 2019
-
Abstract
- A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(iii)–CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochemistry. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biologically active trifluoromethyl enol carboxylic esters. The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALKYNES
*COMPLEX compounds
*CARBOXYLIC acids
*DOSAGE forms of drugs
*ACIDS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 135734808
- Full Text :
- https://doi.org/10.1039/c9cc01173k