pH-responsive catalytic mesocrystals for chemodynamic therapy via ultrasound-assisted Fenton reaction.

Graphical abstract Highlights • Glucose oxidase can be encapsulated in the interior of CaCO 3 particles. • Glucose oxidase can be protected from being damaged in blood circulation. • Ultrasound can improve Fenton reaction efficiency for killing cancer cells. • Ultrasound dosimetry only caused damage at its focal point by exciting sensitizer. Abstract We develop pH-responsive GOD@CaCO 3 -Fe 3 O 4 particles as catalytic nanomedicine for chemodynamic therapy through ultrasound-assisted Fenton reaction. By loading glucose oxidase (GOD) in the interior of the particles, GOD can be well protected and effectively delivered to catalyze glucose in cancer cells. A considerable amount of H 2 O 2 is then generated for Fenton reaction by reacting with Fe 3 O 4 nanoparticles. The introduction of ultrasound irradiation can significantly improve Fenton reaction efficiency in tumors owing to ultrasonic cavitation. Highly toxic hydroxyl radicals are then generated in abundance to kill cancer cells. Good cancer therapeutic effect was realized both in vitro and in vivo via this ultrasound-chemodynamic strategy based on the designed particles, providing a novel strategy for efficient cancer therapy. [ABSTRACT FROM AUTHOR]