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GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity.
- Source :
-
Neuropsychiatric Disease & Treatment . Mar2019, Vol. 15, p657-661. 5p. - Publication Year :
- 2019
-
Abstract
- Purpose: Venlafaxine is one of the commonly prescribed antidepressants for major depressive disorder (MDD). Accumulated evidence revealed the involvement of glutamatergic system in the pathophysiology of MDD and antidepressant treatment.  Methods: We recruited 193 MDD patients who have been taking venlafaxine for 6 weeks, and investigated whether single nucleotide polymorphisms (SNPs) in GSK-3β and BDNF were associated with treatment response. Nine SNPs were selected randomly depending on association studies. Efficacy of treatment was determined by 17-item Hamilton Rating Scale. Allele and genotype frequencies were compared between responders and nonresponders. Results: After adjusting the false discovery rate, no significant difference was observed between response and nonresponse groups in allele or genotype distributions after venlafaxine treatment for 6 weeks. Conclusion: Our results indicated that genetic variants in the GSK-3β and BDNF may not be associated with treatment response in MDD patients treated with venlafaxine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11782021
- Volume :
- 15
- Database :
- Academic Search Index
- Journal :
- Neuropsychiatric Disease & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 135756627
- Full Text :
- https://doi.org/10.2147/NDT.S191376