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Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment.
- Source :
-
Chemical Communications . 4/14/2019, Vol. 55 Issue 29, p4254-4257. 4p. - Publication Year :
- 2019
-
Abstract
- In this study, a folate-targeted pH-sensitive bortezomib conjugate was developed for cancer-specific drug delivery and therapy. The conjugate showed improved cellular uptake, penetration, and anticancer activity compared to free bortezomib, a bortezomib-mannitol derivative, and a PEGylated bortezomib conjugate in folate receptor overexpressing cancer cells and their 3D spheroids. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BORTEZOMIB
*CANCER treatment
*DRUG therapy
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 29
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 135784645
- Full Text :
- https://doi.org/10.1039/c9cc01344j