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LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease.
- Source :
-
Cardiology Research & Practice . 4/16/2019, p1-5. 5p. - Publication Year :
- 2019
-
Abstract
- Background. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results. Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORONARY heart disease risk factors
*DIABETES complications
*BIOMARKERS
*CORONARY disease
*CONFIDENCE intervals
*FACTOR analysis
*GENE expression
*HIGH density lipoproteins
*HYPERTENSION
*INTERLEUKINS
*MULTIVARIATE analysis
*MYOCARDIAL infarction
*RNA
*TRANSCRIPTION factors
*TUMOR necrosis factors
*ODDS ratio
*DISEASE complications
*DIAGNOSIS
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 20908016
- Database :
- Academic Search Index
- Journal :
- Cardiology Research & Practice
- Publication Type :
- Academic Journal
- Accession number :
- 135906057
- Full Text :
- https://doi.org/10.1155/2019/6280194