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Transition Metal‐Free C5 Tosyloxylation of 8‐Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2‐Disulfonyl Hydrazides.
- Source :
-
European Journal of Organic Chemistry . 4/16/2019, Vol. 2019 Issue 14, p2513-2519. 7p. - Publication Year :
- 2019
-
Abstract
- A novel and efficient method for direct tosyloxylation at C5 position of 8‐aminoquinolines has been accomplished by nonmetal‐catalyzed C–H functionalization at mild conditions. It is shown, for the first time, that the radical RSO3· could be generated by the reaction of phenyliodine bistrifluoroacetate with substituted 1,2‐disulfonyl hydrazides. This reaction reveals excellent reactivity, good functional group tolerance, and moderate to good yield. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDRAZIDES
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2019
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 135908389
- Full Text :
- https://doi.org/10.1002/ejoc.201900092