Impact of Machine learning and artificial intelligence on ageing through early prediction of cardiovascular diseases - a review.

Introduction: Machine learning (ML) uses statistical techniques to give computer systems the ability to "learn" from data, without being explicitly programmed. Application of rapid advances in artificial intelligence systems, is expected to revolutionize healthcare in the near future. While cardiovascular diseases are a leading cause of death among elderly in present time, mortality is largely due to late diagnosis. Applied ML can accurately aid early prediction of cardiovascular diseases. The current work aims to review the available literature on applications of artificial intelligence or machine learning in healthcare to predict cardiovascular disease. Method: A literature searches on PubMed database in October 2018 using keywords "(Machine learning or artificial intelligence) & (Cardiovascular OR Heart OR Blood OR vessels OR Cardiac) & Prediction" revealed 1086 citations. However, most did not have machine learning and cardiovascular disease as principal focus. Using filters to allow the appearance of keywords in the title of the paper, limiting to studies including older persons (>65years) we narrowed our results to seven citations of which six which were freely available and are included in our review. Results: Among the early applications, Ong et al in 2012 generated a heart rate variability parameter from five-minute spectrogram and other vital parameters were added to generate a machine learning score which was found to be more accurate than modified early warning score. Liu et al in 2014 in Singapore reported that ML based selection of predictors of Cardiac events gave relevant and significant results. Dames et al, in 2017 found that machine learning of three dimensional right ventricular motion enable outcome prediction in pulmonary hypertension. Weng et al in 2017 in UK have compared four machine learning algorithms with an established algorithm (American college of Cardiology Guidelines) and found that machine learning significantly improves accuracy of cardiovascular risk prediction. Ambala et al in 2017 in USA used random survival forest technique to identify the top 20 predictors of each Cardiovascular Outcome. Conclusions: Our review shows that the impact of machine learning on ageing through early prediction of cardiovascular diseases can no longer be ignored and the field is just warming up. Our work highlights how artificial intelligence is rapidly transforming the way we approach cardiovascular diseases and will be a major game changer in the foreseeable future. [ABSTRACT FROM AUTHOR]